Gene sequence alignments could not be done online due to the length of the capn3 gene, as previously mentioned, and thus I could not produced my own phylogenetic trees. Instead, the tree below was found on ensembl.org and represents the predicted evolutionary history and homologs of the capn3 gene (on the left). The right side shows peptide sequence alignments and conserved protein CAPN3 protein domains.
Capn3 Gene Tree (from: Ensembl)
Discussion
Here we see again the strong conservation of capn3 among primates and rodents, although dog and domestic cow seem to be shown further away here. Branch lengths are consistent to the TreeFam tree and phylograms produced from protein sequence aligmnent (see Protein Phylogeny).
References [1] Vilella AJ, Severin J, Ureta-Vidal A, Durbin R, Heng L, Birney E. EnsemblCompara GeneTrees: Analysis of complete, duplication aware phylogenetic trees in vertebrates. Genome Research 2008 Nov 4
Last Updated 7.17.2012 This page was created by Pavlos Bousounis. Contact: [email protected]